Ramsey, Douglas and Vagabonds mens sides are all in action this weekend.
Douglas for their part have a difficult trip to Regional 2 North West leaders North Ribblesdale.
The Port-e-Chee side need a win to secure a playoff spot and did beat this weekend’s opponents 26-22 when they visited the island earlier in the season.
Douglas said: “Brandon Haas isn’t available so Josh Campbell moves back in to the front row and John Dutnall comes in at flanker.
“In the backs only Matty Wood doesn’t make the trip so Harry Hewson slots back into his usual outside centre position.”
In the Counties Three Minor Conference, both Ramsey and Vagas are at home.
Ramsey face Ormskirk at Mooragh Park while Hoylake are the guests at Ballafletcher.